miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways
Guoshu Bi, Jiaqi Liang, Mengnan Zhao, Huan Zhang, Xing Jin, Tao Lu, Yuansheng Zheng, Yunyi Bian, Zhencong Chen, Yiwei Huang, Valeria Besskaya, Cheng Zhan, Qun Wang, Lijie Tan
Abstract
. Moreover, we found that GMDS-AS1 and LINC01128 sensitized LUAD cells to CDDP/PEM by sponging miR-6077. Collectively, these results imply the critical role of miR-6077 in LUAD's sensitivity to CDDP/PEM, thus providing a novel therapeutic strategy for overcoming chemoresistance in clinical practice.
Topics & Concepts
CisplatinPemetrexedCancer researchCell cycle checkpointCell cycleCyclin-dependent kinase 1microRNAApoptosisAdenocarcinomaMedicineBiologyChemotherapyCancerInternal medicineGeneBiochemistryRNA modifications and cancerMicroRNA in disease regulationFerroptosis and cancer prognosis