Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions
Yu Li, Qing Xiao, Jie Tang, Lidan Xiong, Li Li
Abstract
Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.
Topics & Concepts
Extracellular vesiclesSkin cancerHuman skinMedicineSkin AgingCancer researchCancerBiologyCell biologyDermatologyInternal medicineGeneticsExtracellular vesicles in diseaseInflammasome and immune disordersIL-33, ST2, and ILC Pathways