Renal Prognosis of COVID-19 Associated Nephropathy
Gabriel Giannini, Juan Carlos Q. Velez, Rebecca M. May, Shree Sharma, Muner Mohamed, Clarissa A. Cassol, Christopher P. Larsen, Tiffany Caza
Abstract
COVID-19 associated nephropathy (COVAN) is the most common cause of acute kidney injury (AKI) in Black patients with SARS-CoV-2 infection undergoing kidney biopsy. It presents with AKI and proteinuria, often nephrotic-range. The histopathology of COVAN is collapsing glomerulopathy (CG), the most severe form of focal segmental glomerulosclerosis.1 The pattern of injury of CG is also seen in the setting of other infections (including human immunodeficiency virus, human T-cell lymphotrophic virus-1, filariasis, leishmaniasis, parvovirus B19, cytomegalovirus, and loa loa), autoimmune disease, ischemia, anabolic steroids, and therapeutic or recreational drugs.