Marginal regression models for recurrent and terminal events
Lin, DY, Debashis Ghosh
Abstract
A major complication in the analysis of recurrent event data from med- ical studies is the presence of death. We consider the marginal mean function for the cumulative number of recurrent events over time, acknowledging the fact that death precludes further recurrences. We specify that covariates have multiplicative effects on an arbitrary baseline mean function while leaving the stochastic structure of the recurrent event process completely unspecified. We then propose estimators for the regression parameters and the baseline mean function under this semipara- metric model. The asymptotic properties of these estimators are established. Joint inferences about recurrent events and death are also discussed. The finite-sample behavior of the proposed inference procedures is assessed through simulation stud- ies. An application to a well-known bladder tumor study is provided.