Network pharmacology-based analysis of the mechanism of <i>Saposhnikovia divaricata</i> for the treatment of type I allergy
Xiangsheng Li, Hui Li, Tingting Wang, Yang Zhao, Yuxin Shao, Yizhao Sun, Yanfen Zhang, Zhongcheng Liu
Abstract
CONTEXT: (Turcz.) Schischk (Apiaceae) (SD) has various pharmacological activities, but its effects on type I allergy (TIA) have not been comprehensively studied. OBJECTIVE: This study evaluates the treatment and molecular mechanisms of SD against TIA. MATERIALS AND METHODS: -glucosylcimifugin (POG, 10, 40, and 80 μg/mL) and the positive control drug-ketotifen fumarate (KF, 30 μM) for 12 h, then subjected to cell degranulation and qPCR analysis. RESULTS: < 0.05). SD and POG could down-regulate the expression of related proteins in the Lyn/Syk, PI3K/AKT and MAPK signalling pathways. DISCUSSION AND CONCLUSION: could inhibit IgE-induced degranulation of mast cells, providing a scientific basis for further research and clinical applications of SD in TIA treatment.