Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site
Katja Silbermann, Jiyang Li, Vigneshwaran Namasivayam, Sven Marcel Stefan, Michael Wiese
Topics & Concepts
Abcg2ChemistryMultiple drug resistancePharmacologyABCC1ATP-binding cassette transporterIC50TransporterSKBR3CalceinDrugIn vitroCancer cellBiochemistryCancerMedicineInternal medicineAntibioticsGeneHuman breastMembraneDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesHIV/AIDS drug development and treatment