Radical-polar crossover reaction of glycine derivatives
Youwan Ye, Xin Zhang, Peng Kong, Yong Yuan, Xiaolong Zhao, Congde Huo
Abstract
Here we report a visible-light facilitated radical addition strategy for the preparation of various natural or unnatural α-amino acids from readily available glycine derivatives and alkenes. A key aspect in achieving this side carbon chain introduction reaction, while circumventing the well-documented cyclization pathway, was the employment of a radical-polar crossover strategy under redox neutral conditions.
Topics & Concepts
ChemistryGlycineCrossoverPolarRedoxSide chainRadicalAmino acidCombinatorial chemistryRadical initiatorPhotochemistryOrganic chemistryBiochemistryComputer sciencePolymerAstronomyPolymerizationPhysicsArtificial intelligenceRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques