An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation
Son C. Le, Huanghe Yang
Abstract
site in TMEM16A, defines its functional importance in channel gating, and provides insight into a long-range allosteric gating mechanism of TMEM16 channels and scramblases.
Topics & Concepts
Allosteric regulationGatingBinding siteChemistryBiophysicsTransmembrane proteinIntracellularTransmembrane domainBiochemistryCell biologyBiologyReceptorIon channel regulation and functionIon Transport and Channel RegulationNeuroscience and Neuropharmacology Research