Rapid and highly sensitive visual detection of oxalate for metabolic assessment of urolithiasis <i>via</i> selective recognition reaction of CdTe quantum dots
Piaopiao Chen, Yunjin Bai, Yin Tang, Shixin Yan, Xinyi Wang, Wuran Wei, Jia Wang, Ming Zhang, Binwu Ying, Jia Geng
Abstract
, which can be selectively recognized by CdTe QDs. The homogeneous sensing system shows high sensitivity for oxalate detection in the range of 0.1 μM to 10 mM within 6 min; moreover, the visual detection of 10 μM oxalate could be achieved by the naked eye. Our method was tested on 53 clinical samples; it showed 100% specificity and sensitivity for calcium oxalate urolithiasis compared with clinical diagnosis, even for hematuria samples. Furthermore, this method can be expanded to other wide range of biochemistry applications for medical diagnosis and point-of-care testing.
Topics & Concepts
OxalateQuantum dotQuenching (fluorescence)Cadmium telluride photovoltaicsHomogeneousMaterials scienceCombinatorial chemistryChemistryInorganic chemistryNanotechnologyOpticsFluorescencePhysicsThermodynamicsKidney Stones and Urolithiasis TreatmentsPediatric Urology and Nephrology StudiesSelenium in Biological Systems