GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos
Erwei Zuo, Yidi Sun, Wei Wu, Tanglong Yuan, Wenqin Ying, Hao Sun, Liyun Yuan, Lars M. Steinmetz, Yixue Li, Hui Yang
Topics & Concepts
Genome editingGenomeBiologyComputational biologyCRISPRGeneticsCas9Cancer genome sequencingEmbryonic stem cellGenomicsGeneCRISPR and Genetic EngineeringEvolution and Genetic DynamicsGenetics, Aging, and Longevity in Model Organisms