Combined effect of Polymyxin B and Tigecycline to overcome Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae
Yuan Tian, Qiaoyu Zhang, Li-Rong Wen, JianSen Chen
Abstract
. Unfortunately, tigecycline resistance and colistin heteroresistance are also increasing rapidly. In the current study, we identified a high prevalence of heteroresistance to both PMB and TGC among clinical isolates of carbapenem-resistant K. pneumoniae (CRKP). The resistant subpopulations could survive pressure from TGC or PMB but were killed by the combination at a relatively low dose. It is proposed that the combination of PMB and TGC may be a treatment strategy for patients who are infected with CRKP heteroresistant to PMB or TGC.
Topics & Concepts
Klebsiella pneumoniaeTigecyclineMicrobiologyBiologyEffluxAcinetobacter baumanniiCarbapenemPopulationPolymyxin BBacteriaAntibioticsMedicineGenePseudomonas aeruginosaEscherichia coliGeneticsEnvironmental healthAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPneumocystis jirovecii pneumonia detection and treatment