Conveyance of cortical pacing for parkinsonian tremor-like hyperkinetic behavior by subthalamic dysrhythmia
Chen‐Syuan Huang, Guan‐Hsun Wang, Hsiang-Hao Chuang, Ai‐Yu Chuang, Jui‐Yu Yeh, Yi‐Chen Lai, Ya‐Chin Yang
Abstract
channel inhibition. Excessive top-down-triggered subthalamic burst discharges then drive highly correlative activities bottom-up in the motor cortices and skeletal muscles. This leads to hyperkinetic behaviors such as tremors, which are effectively ameliorated by inhibition of cortico-subthalamic AMPAergic synaptic transmission. We conclude that subthalamic burst discharges play an imperative role in cortico-subcortical information relay, and they critically contribute to the pathogenesis of both hypokinetic and hyperkinetic parkinsonian symptoms.
Topics & Concepts
NeuroscienceSubthalamic nucleusGlutamatergicResting tremorBurstingParkinson's diseasePsychologyMedicineDeep brain stimulationDiseaseGlutamate receptorDopamineInternal medicineDopaminergicReceptorNeurological disorders and treatmentsParkinson's Disease Mechanisms and TreatmentsGenetic Neurodegenerative Diseases