Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19
Madhav V. Dhodapkar, Kavita M. Dhodapkar, Rafi Ahmed
Abstract
Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the efficacy of emerging COVID-19 vaccines in this patient population as well and warrant the need to systematically study natural and vaccine-induced virus-specific immunity in these patients.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)VirologyImmunity2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologyMedicineHematologic NeoplasmsImmune systemCancerInfectious disease (medical specialty)Internal medicineDiseaseOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 and healthcare impactsCOVID-19 Clinical Research Studies