Ball milling – a new concept for predicting degradation profiles in active pharmaceutical ingredients
Reinhard P. Kaiser, Everaldo F. Krake, Laura Backer, Jonas Urlaub, Wolfgang Baumann, Norbert Handler, Helmut Buschmann, Torsten Beweries, Ulrike Holzgrabe, Carsten Bolm
Abstract
A method for forced oxidative mechanochemical degradation of active pharmaceutical ingredients (APIs) using clopidogrel hydrogensulfate as a model compound is presented. Considerable and selective formation of degradants occurs already after very short reaction times of less than 15 minutes and the nature of the products is strongly dependent on the used oxidant.
Topics & Concepts
Active ingredientChemistryDegradation (telecommunications)Ball millCombinatorial chemistryOrganic chemistryChromatographyChemical engineeringPharmacologyComputer scienceEngineeringTelecommunicationsMedicineAnalytical Methods in PharmaceuticalsAnalytical Chemistry and ChromatographyAnalytical chemistry methods development