Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
Wen Ren, Yuling Deng, J. WARD, Rebecca Vairin, Ruoli Bai, Hashini Wanniarachchi, Khagendra B. Hamal, Pouguiniseli E. Tankoano, C. Tamminga, Lorena M.A. Bueno, Ernest Hamel, Ralph P. Mason, Mary Lynn Trawick, Kevin G. Pinney
Topics & Concepts
CombretastatinTubulinChemistryColchicineCancer cellCytotoxicityIndole testMicrotubule polymerizationMicrotubuleBiochemistryPharmacologyStereochemistryCancerIn vitroBiologyCell biologyGeneticsSynthesis and biological activitySynthesis of heterocyclic compoundsBioactive Compounds and Antitumor Agents