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Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization

Wen Ren, Yuling Deng, J. WARD, Rebecca Vairin, Ruoli Bai, Hashini Wanniarachchi, Khagendra B. Hamal, Pouguiniseli E. Tankoano, C. Tamminga, Lorena M.A. Bueno, Ernest Hamel, Ralph P. Mason, Mary Lynn Trawick, Kevin G. Pinney

2023European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

CombretastatinTubulinChemistryColchicineCancer cellCytotoxicityIndole testMicrotubule polymerizationMicrotubuleBiochemistryPharmacologyStereochemistryCancerIn vitroBiologyCell biologyGeneticsSynthesis and biological activitySynthesis of heterocyclic compoundsBioactive Compounds and Antitumor Agents
Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization | Litcius