Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Rowan Hardy, Gareth G. Lavery, Michael A. Matthay, Babu Naidu, Gavin D. Perkins, David Thickett
Abstract
<b>ARDS patients have decreased alveolar macrophage efferocytosis, which is associated with increased alveolar inflammation, and may contribute to worse clinical outcomes, including mortality. Upregulation of efferocytosis may offer a therapeutic strategy.</b>https://bit.ly/2Q7REdM
Topics & Concepts
EfferocytosisMedicineAlveolar macrophageARDSRespiratory distressAcute respiratory distressMacrophageMacrophage activation syndromeInflammationIntensive care medicineLungImmunologyInternal medicineSurgeryDiseaseBiochemistryIn vitroChemistryPhagocytosis and Immune RegulationImmune cells in cancerRespiratory Support and Mechanisms