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Nickel-catalyzed asymmetric reductive aryl-allylation of unactivated alkenes

Zhiyang Lin, Youxiang Jin, Weitao Hu, Chuan Wang

2021Chemical Science52 citationsDOIOpen Access PDF

Abstract

A nickel-catalyzed reductive asymmetric aryl-allylation of tethered unactivated alkenes has been developed, providing diverse benzene-annulated cyclic compounds bearing a quaternary stereocenter with high regio-, <italic>E</italic>/<italic>Z</italic>- and enantio-selectivity.

Topics & Concepts

ArylCatalysisNickelChemistryReductive eliminationCombinatorial chemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis
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