Nickel-catalyzed cross-coupling aminations <i>via</i> high-throughput mechanochemistry enabled by resonant acoustic mixing
Alice Nanni, Deshen Kong, Chen Zhu, Magnus Rueping
Abstract
Resonant Acoustic Mixing (RAM) allows High Throughput Experimentation (HTE) using commercially available 96-well plates as exemplified by the nickel catalyzed C–N cross coupling of aryl halides with different amine and anilines.
Topics & Concepts
CatalysisNickelMixing (physics)HalideCoupling (piping)ThroughputArylAmine gas treatingMaterials scienceMechanochemistryChemistryInorganic chemistryNanotechnologyMetallurgyOrganic chemistryComputer sciencePhysicsTelecommunicationsWirelessAlkylQuantum mechanicsInnovative Microfluidic and Catalytic Techniques InnovationCatalytic Cross-Coupling ReactionsLuminescence and Fluorescent Materials