Recent Advances on Biological Activities and Structural Modifications of Dehydroabietic Acid
Meng Hao, Jianwei Xu, Houpeng Wen, Jiawei Du, Shaoyong Zhang, Min Lv, Huiyan Xu
Abstract
Dehydroabietic acid is a tricyclic diterpenoid resin acid isolated from rosin. Dehydroabietic acid and its derivatives showed lots of medical and agricultural bioactivities, such as anticancer, antibacterial, antiviral, antiulcer, insecticidal, and herbicidal activities. This review summarized the research advances on the structural modification and total synthesis of dehydroabietic acid and its derivatives from 2015 to 2021, and analyzed the biotransformation and structure-activity relationships in order to provide a reference for the development and utilization of dehydroabietic acid and its derivatives as drugs and pesticides.
Topics & Concepts
BiotransformationTerpenoidDiterpeneRosinChemistryAbietic acidOrganic chemistryResin acidStereochemistryEnzymeBiological Activity of Diterpenoids and BiflavonoidsNatural product bioactivities and synthesisPlant biochemistry and biosynthesis