From Magic Bullet to Magic Bomb: Reductive Bioactivation of Antiparasitic Agents
Sergio Wittlin, Pascal Mäser
Abstract
. Here we provide an overview on the molecular basis of selectivity of antiparasitic drug action with particular reference to the ozonides, the new generation of antimalarial peroxides designed by Jonathan Vennerstrom.
Topics & Concepts
Magic bulletAntiparasiticAntiparasitic agentProdrugPlasmodium falciparumArtemisininBiologyDrugMode of actionInfectious disease (medical specialty)ChemistryPharmacologyMalariaBiochemistryImmunologyMedicineDiseaseBioinformaticsPathologyTrypanosoma species research and implicationsMalaria Research and ControlResearch on Leishmaniasis Studies