Developing a Novel Anticancer Gold(III) Agent to Integrate Chemotherapy and Immunotherapy
Juzheng Zhang, Ming Jiang, Shanhe Li, Zhenlei Zhang, Hongbin Sun, Feng Yang, Hong Liang
Abstract
NPs could integrate chemotherapy and immunotherapy by synergistically attacking two different cellular components in TME at the same time, namely, polarizing the tumor-associated macrophages and inducing apoptosis of gastric cancer cells.
Topics & Concepts
In vivoChemistryCytotoxicityIn vitroImmunotherapyChemotherapyCancer immunotherapyCancer cellCancer researchPharmacologyCancerBioavailabilityTumor microenvironmentTumor cellsBiochemistryMedicineInternal medicineBiologyBiotechnologyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsPhagocytosis and Immune Regulation