Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII
Süleyman Akocak, Özlen Güzel-Akdemir, Rajesh Kishore Kumar Sanku, Samson S. Russom, Bogdan I. Iorga, Claudiu T. Supuran, Marc A. Ilies
Topics & Concepts
Carbonic anhydraseChemistryPyridiniumIsozymeGene isoformCytosolEnzymeStereochemistryDocking (animal)Carbonic anhydrase IIBiochemistryActive siteTransmembrane proteinReceptorMedicinal chemistryMedicineNursingGeneEnzyme function and inhibitionSynthesis and Catalytic ReactionsChemical Reactions and Mechanisms