The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy
Panpan Hou, Tian Tian, Penghui Jia, Yuxin Lin, Zibo Li, Yicheng Wang, Yu Ye, Chunmei Li, Deyin Guo
Abstract
-knockout mice are more susceptible to dextran-sulfate (DSS)-induced colitis and exhibit more severe gut inflammation with elevated NLRP3 inflammasome activity, suggesting a protective role of CCDC50 in the pathology and progression of inflammatory bowel disease (IBD). Our finding reveals a function of autophagy-related proteins in the regulation of NLRP3-mediated inflammation, thus demonstrating the intricate crosstalk between autophagy and inflammation.
Topics & Concepts
InflammasomeAutophagyInflammationCrosstalkBiologyCell biologyHMGB1ATG16L1Caspase 1ImmunologyApoptosisBiochemistryPhysicsOpticsInflammasome and immune disordersAutophagy in Disease and TherapyPhagocytosis and Immune Regulation