Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis
Xiuxing Jiang, Xiangtao Huang, Guoxun Zheng, Guanfei Jia, Zhiqiang Li, Xin Ding, Lei Ling, Liang Yuan, Shuangnian Xu, Ning Gao
Abstract
Our study underscored the potential of therapeutic targeting of PI4KA to overcome chemoresistance in leukemia. A combination of the PI4KA inhibitor with classic chemotherapeutic agents could represent a novel therapeutic strategy for the treatment of refractory leukemia.
Topics & Concepts
LeukemiaIn vivoCancer researchMedicinePharmacologyChemistryBiologyImmunologyBiotechnologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysAcute Myeloid Leukemia Research