Development of Robust, Efficient and Scalable Transition Metal Catalyzed Transformations: Translation of Reactions from Micromole to Multi-Kilogram Scale Processes
Jacob M. Ganley, Candice L. Joe, Eric M. Simmons
Abstract
Mixing effects Particle size Metal precursor and ligand selection Reagent stoichiometry Liquid-liquid biphasic mixtures Adventitious water effects Precatalyst formation and activation Extended unit operation times Liquid-solid biphasic mixtures Solvent selection Catalyst deactivation Liquid-gas biphasic mixtures Heterogeneous catalysts Grinding effects of stir bars Poisoning by input-related impurities
Topics & Concepts
CatalysisKilogramScale (ratio)ScalabilityTranslation (biology)Transition metalComputer scienceChemistryPhysicsBody weightDatabaseOrganic chemistryMedicineGeneInternal medicineQuantum mechanicsBiochemistryMessenger RNAInnovative Microfluidic and Catalytic Techniques InnovationNanomaterials for catalytic reactionsCatalytic Cross-Coupling Reactions