Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
Philippe Pihán, Fernanda Lisbona, Janina Borgonovo, Sandra Edwards‐Jorquera, Paula Nunes, Karen Castillo, Oliver Kepp, Hery Urra, Suvi Saarnio, Helena Vihinen, Amado Carreras‐Sureda, Sabrina Forveille, Allan Sauvat, Daniela De Giorgis, Amaury Pupo, Diego A. Rodríguez, Giovanni Quarato, Alfredo Sagredo, Fernanda Lourido, Anthony Letai, Ramón Latorre, Guido Kroemer, Nicolas Demaurex, Eija Jokitalo, Miguel L. Concha, Álvaro Glavic, Douglas R. Green, Claudio Hetz
Abstract
and zebrafish models. Our results unveil an unanticipated function for RECS1 as a proapoptotic component of the TMBIM family that ignites cell death programs at lysosomes.
Topics & Concepts
Cell biologyProgrammed cell deathApoptosisCalciumZebrafishBiologyMitochondrionCellChemistryBiochemistryOrganic chemistryGeneAutophagy in Disease and TherapyCellular transport and secretionCalcium signaling and nucleotide metabolism