Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism
Negin Mosalmanzadeh, Brandt D. Pence
Abstract
Modified cholesterols such as oxidized low-density lipoprotein (OxLDL) contribute to atherosclerosis and other disorders through the promotion of foam cell formation and inflammation. In recent years, it has become evident that immune cell responses to inflammatory molecules such as OxLDLs depend on cellular metabolic functions. This review examines the known effects of OxLDL on immunometabolism and immune cell responses in atherosclerosis and several other diseases. We additionally provide context on the relationship between OxLDL and aging/senescence and identify gaps in the literature and our current understanding in these areas.
Topics & Concepts
Context (archaeology)InflammationImmune systemLipoproteinImmunologyLow-density lipoproteinFoam cellSenescenceBiologyMedicineCell biologyCholesterolBiochemistryPaleontologyAtherosclerosis and Cardiovascular DiseasesAntioxidant Activity and Oxidative StressCholesterol and Lipid Metabolism