Isolation and characterization of auronlignan derivatives with hepatoprotective and hypolipidemic activities from the fruits of <i>Hippophae rhamnoides</i> L.
Qinge Ma, Guan Yang, Zhipei Sang, Jianghong Dong, Rongrui Wei
Abstract
L. for the first time, and their structures were determined by extensive and comprehensive IR, UV, NMR, MS spectral analyses and compared with the reported references. Among them, compounds 1, 4, 7, 11, 15, and 19 showed moderate hepatoprotective activities against the damage in acetaminophen-induced HepG2 cells; compounds 2, 5, 8, and 12 exhibited moderate inhibition of pancreatic lipase activity, and decreased the moderately FFA-induced lipid accumulation in HepG2 liver cells. The plausible biogenetic pathway and preliminary structure-activity relationship of the selected compounds are scientifically summarized and discussed in this study.
Topics & Concepts
Hippophae rhamnoidesTraditional medicineFunctional foodIsolation (microbiology)BiologyFood scienceMedicineMicrobiologyPhytochemical and Pharmacological StudiesMedicinal plant effects and applicationsBotanical Studies and Applications