Amplification of the Chromosomal <i>bla</i> <sub>CTX-M-14</sub> Gene in Escherichia coli Expanding the Spectrum of Resistance under Antimicrobial Pressure
Eun-Jeong Yoon, You Jeong Choi, Dokyun Kim, Dongju Won, Jong Rak Choi, Seok Hoon Jeong
Abstract
Increasing prevalence of E. coli producing CTX-M ESBL is a major concern in clinical settings because it significantly limits treatment options. Thus, it is important to keep watching current molecular mechanisms of resistance and the scheme for dissemination.
Topics & Concepts
BiologyEscherichia coliGeneGeneticsPlasmidChromosomeGene dosageCephalosporinAntibiotic resistanceGene duplicationAntibioticsGene expressionAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsAntibiotics Pharmacokinetics and Efficacy