Development of Potent <i>Pf</i> CLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials
Amit Mahindra, Omar Janha, Kopano Mapesa, Ana Sanchez-Azqueta, Mahmood M. Alam, Alfred Amambua‐Ngwa, Davis Nwakanma, Andrew B. Tobin, Andrew G. Jamieson
Abstract
CLK3.
Topics & Concepts
Plasmodium falciparumChemistryMechanism of actionChloroquineDrugMalariaDrug developmentRNA splicingProtein kinase AKinaseComputational biologyPharmacologyBiochemistryGeneIn vitroRNABiologyImmunologyMalaria Research and ControlMosquito-borne diseases and controlComputational Drug Discovery Methods