A multimodal strategy of Fe<sub>3</sub>O<sub>4</sub>@ZIF-8/GOx@MnO<sub>2</sub>hybrid nanozyme<i>via</i>TME modulation for tumor therapy
Yu Zhang, Yifeng Yang, Jinsheng Shi, Lili Wang
Abstract
and GOx as oxidase, and Fe(II) as catalase-like, and ablated the primary tumor. Moreover, the hybrid nanozyme can facilitate the transformation of M2-type macrophages to M1-type, and strong systemic antitumor immune effect was induced. A synergy of multiple therapeutic modes including starvation therapy, CDT, photothermal therapy (PTT), and immunotherapy can be realized in the hybrid nanozyme for tumor therapy.
Topics & Concepts
Tumor microenvironmentGlucose oxidasePhotothermal therapyGluconic acidChemistryCancer researchHydrogen peroxideCombination therapyImmunotherapyBiophysicsMaterials scienceCancerNanotechnologyBiochemistryTumor cellsEnzymePharmacologyMedicineBiologyInternal medicineNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery