Biological functions of m6A methyltransferases
Jianzhong Gu, Yu Zhan, Lvjia Zhuo, Qin Zhang, Guohua Li, Qiujie Li, Shasha Qi, Jinyu Zhu, Qun Lv, Yingying Shen, Yong Guo, Shuiping Liu, Tian Xie, Xinbing Sui
Abstract
Abstract M 6 A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m 6 A methyltransferases and explain their close connections to each other. Then, we concentrate on the extensive biological functions of m 6 A methyltransferases, which include cell growth, nerve development, osteogenic differentiation, metabolism, cardiovascular system homeostasis, infection and immunity, and tumour progression. We summarize the currently unresolved problems in this research field and propose expectations for m 6 A methyltransferases as novel targets for preventive and curative strategies for disease treatment in the future.