Tandem Construction of Indole-Fused Phthalazines from (2-Alkynylbenzylidene)hydrazines under Metal-Free Conditions
Zhaojiang Shi, Lianhui Wang, Zi Yang, Lianghua Jie, Xiao Liu, Xiuling Cui
Abstract
An efficient approach to invent diversely substituted indole-fused phthalazines from in situ formed (2-alkynylbenzylidene)hydrazines under metal-free conditions via selective radical cyclization has been developed. Notably, this 6-exo-dig addition–cyclization tandem procedure proceeds under air atmosphere and shows a broad substrate suitability, as well as avoids harmful byproducts, which complies with the concept of green synthesis.
Topics & Concepts
ChemistryTandemIndole testCombinatorial chemistrySubstrate (aquarium)Organic chemistryMetalMaterials scienceComposite materialGeologyOceanographyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions