Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs
Mengmiao Zhao, Kan Yang, Xinyue Zhu, Tian Gao, Wei Yu, Han Liu, Zhi‐Hao You, Zhenming Liu, Xiaoqiang Qiao, Yali Song
Topics & Concepts
ChemistryDocking (animal)PyrimidineIndole testMTT assayHistone deacetylaseCytotoxicityStereochemistryCell cultureTopoisomeraseCancer cellApoptosisAcetylationEnzymeBiochemistryIn vitroHistoneCancerGeneBiologyMedicineNursingGeneticsCancer therapeutics and mechanismsHistone Deacetylase Inhibitors ResearchSynthesis and bioactivity of alkaloids