Activation of the PPARγ/NF-κB pathway by A-MPDA@Fe<sub>3</sub>O<sub>4</sub>@PVP <i>via</i> scavenging reactive oxygen species to alleviate hepatic ischemia-reperfusion injury
Dong Mo, Wei Cui, Linxin Chen, Juanjuan Meng, Yuting Sun, Kaiyong Cai, Jixi Zhang, Jianrong Zhang, Kui Wang, Xiaohe Luo
Abstract
@PVP can further protect liver tissue by activating the PPARγ/NF-κB pathway. This multiplex antioxidant enzyme therapy can provide new references for the treatment of IRI in organ transplantation and other ROS-related injuries such as fibrosis, cirrhosis, and bacterial and hepatic viral infection.
Topics & Concepts
Reactive oxygen speciesReperfusion injuryNF-κBScavengingIschemiaOxygenImmune systemPeroxisome proliferator-activated receptorPharmacologyChemistrySignal transductionBiologyReceptorImmunologyBiochemistryMedicineInternal medicineAntioxidantOrganic chemistryAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsSulfur Compounds in Biology