Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa
Malligarjunan Rajavel, Vijay Kumar, Ha Nguyen, Jacob Wyatt, Steven H. Marshall, Krisztina M. Papp‐Wallace, Prasad Deshpande, Satish Bhavsar, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel, Robert A. Bonomo, Focco van den Akker
Abstract
Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.
Topics & Concepts
Penicillin binding proteinsPseudomonas aeruginosaChemistryMicrobiologyEscherichia coliBiochemistryBiologyBacteriaGeneGeneticsAntibiotic Resistance in BacteriaPneumocystis jirovecii pneumonia detection and treatmentAntibiotics Pharmacokinetics and Efficacy