Hydrogen bonding enhanced drug–polymer interaction for efficient drug loading and delivery
Xiaotian Qu, Junran Li, Yishu Yu, Jie Yang
Abstract
A carrier design strategy of hydrogen bonding enhanced drug-carrier interaction is developed to prepare a polymeric nanomedicine with high drug loading content and superb loading efficiency. Moreover, a morphology transition from spherical to cylindrical micelles is observed upon increasing drug loading content, which can open up a new way for controlling the morphology of the polymeric nanomedicine.
Topics & Concepts
NanomedicineDrug deliveryPolymerDrugHydrogen bondMaterials scienceNanotechnologyMicelleChemical engineeringChemistryNanoparticleComposite materialOrganic chemistryMoleculeAqueous solutionPharmacologyEngineeringMedicineNanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationPolymer Surface Interaction Studies