A microRNA-gated thgRNA platform for multiplexed activation of gene expression in mammalian cells
Victoria M. Hunt, Wilfred Chen
Abstract
strand displacement. This new AND-gate design is exploited to elicit conditional protein degradation based on induced expression of a specific ubiquibody. This new strategy may find many new applications in an RNA-responsive manner.
Topics & Concepts
microRNAGene expressionGeneMessenger RNACell biologyRNADegradation (telecommunications)Computational biologyChemistryMolecular biologyBiologyGeneticsComputer scienceTelecommunicationsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryCRISPR and Genetic Engineering