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Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose

Matthew S. Krantz, Jason Kwah, Cosby A. Stone, Elizabeth J. Phillips, Gilbert Ortega, Aleena Banerji, Kimberly G. Blumenthal

2021JAMA Internal Medicine97 citationsDOIOpen Access PDF

Abstract

5%; 95% CI, 4%-6%; low/moderate, 7%; 95% CI, 6%-9%; high, 11%; 95% CI, 7%-15%), anxiolytics/sedatives (no loneliness, 9%; 95% CI, 7%-10%; low/moderate, 12%; 95% CI, 10%-14%; high, 20%; 95% CI, 15%-25%), antidepressants (no loneliness, 14%; 95% CI, 12%-16%; low/moderate, 19%; 95% CI, 16%-21%; high, 27%; 95% CI, 21%-33%), and polypharmacy (no loneliness, 41%; 95% CI, 38%-43%; low/moderate, 44%; 95% CI, 41%-47%; high, 50%; 95% CI, 44%-56%) (Figure ), and there was a nonsignificant trend for opioid use (no loneliness: 7%; 95% CI, 5%-8%; low/moderate, 7%; 95% CI, 6%-9%; high, 10%; 95% CI, 6%

Topics & Concepts

MedicineCoronavirus disease 2019 (COVID-19)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakInternal medicineInfectious disease (medical specialty)OutbreakDiseaseFood Allergy and Anaphylaxis ResearchDrug-Induced Adverse ReactionsSARS-CoV-2 and COVID-19 Research