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The state-of-the-art preparation, purification and biological activities of mannan oligosaccharides

Jili Liao, Bowen Yan, Chenhuan Lai, Kui Zeng, Ye Yang, Yanzhu Zhu, Baishuang Yin, Caoxing Huang

2025Industrial Crops and Products11 citationsDOIOpen Access PDF

Abstract

Mannan oligosaccharides (MOSs), a class of functionally edible oligosaccharides, show a range of advantages given its abundant, sustainable, bioactive, and biocompatible properties. They have been widely applied into the fields of pharmaceutical, food and feed industries. To fully understand the progress of the preparation and biological activities of MOSs in these fields in decades, we summarized and compared various techniques for the preparation of MOSs from yeast cell walls and different plants. As well, diverse techniques for the separation and purification of MOSs have been reviewed in details. More importantly, their biological activities, such as effectively improve the intestinal microbial environment, improve the body's immunity, reduce blood glucose and blood lipids, and improve animal growth performance, are clearly discussed in this review. The applications of MOSs in the field of functional foods are also summarized. This review endeavors to function as a primer for individuals with a scholarly interest in prebiotic research, offering a foundational perspective for delving into the intricate domain of bio-based molecular taxonomy. This paper reviews the methods of preparation and isolation and purification of MOSs, and discusses the biological activities of MOSs in terms of their structure and composition. ● The preparation methods of mannan oligosaccharides(MOSs) were summarized. ● The methods of separation and purification of MOSs were summarized. ● The abundant bioactivities of MOSs are described in detail. ● The biological activites of MOSs were discussed with its structure and composition.

Topics & Concepts

MannanChemistryOligosaccharideBiochemistryChromatographyPolysaccharideCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchEnzyme Production and Characterization