Antifungal Susceptibility of Clinical Yeast Isolates from a Large Canadian Reference Laboratory and Application of Whole-Genome Sequence Analysis To Elucidate Mechanisms of Acquired Resistance
Lisa R. McTaggart, Ana Cabrera, Kirby Cronin, Julianne V. Kus
Abstract
To understand the epidemiology and susceptibility patterns of yeast infections in Ontario, Canada, we examined 4,715 clinical yeast isolates submitted to our laboratory for antifungal susceptibility testing from 2014 to 2018. Candida albicans was the most frequently submitted species (43.0%), followed by C. glabrata (21.1%), C. parapsilosis (15.0%), and C. tropicalis (6.2%). Twenty-three other Candida spp.
Topics & Concepts
CaspofunginBiologyMicrobiologyCandida tropicalisCandida glabrataAnidulafunginEchinocandinMicafunginFluconazoleCandida parapsilosisCorpus albicansCandida albicansAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesYeasts and Rust Fungi Studies