The Significance of Mitochondrial Dysfunction in Cancer
Yongde Luo, Jianjia Ma, Weiqin Lu
Abstract
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial dysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summarize mitochondrial dysfunction induced by these alterations that promote human cancers.
Topics & Concepts
Mitochondrial DNAMitochondrionDNAJA3BiologyCell biologyOxidative stressOncogeneApoptosisOxidative phosphorylationOrganelleMutationCancer researchmitochondrial fusionCell cycleGeneticsGeneBiochemistryMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismATP Synthase and ATPases Research