Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments
Lei Gan, Miriam De J. Velásquez-Hernández, Anita Emmerstorfer‐Augustin, Peter Wied, Heimo Wolinski, Simone Dal Zilio, Marcello B. Solomon, Weibin Liang, Christian J. Doonan, Paolo Falcaro
Abstract
Living cells are coated with a multi-layered MOF biocomposite shell: the shell dissolution releases a biotherapeutic (antitrypsin) that provides artificial adaptability to protease-rich environments.
Topics & Concepts
ProteaseDissolutionViability assayCytotoxic T cellChemistryMetal-organic frameworkComposite numberChemical engineeringYeastMoleculeMaterials scienceBiophysicsNanotechnologyCellIn vitroBiochemistryEnzymeOrganic chemistryAdsorptionBiologyComposite materialEngineeringMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers