Dietary nitrate reduces blood pressure and cerebral artery velocity fluctuations and improves cerebral autoregulation in transient ischemic attack patients
Jui‐Lin Fan, Terrence O’Donnell, Jeremy Lanford, Kevin D. Croft, Eloise Watson, Duncan Smyth, Henrietta Koch, Lai-Kin Wong, Yu‐Chieh Tzeng
Abstract
We found dietary nitrate supplementation reduced blood pressure and brain blood flow fluctuations and improved the relationship between blood pressure and brain blood flow in transient ischemic attack patients. Meanwhile, dietary nitrate had no effects on the brain blood vessels’ response to CO 2 . We attribute the improved brain blood flow stability to the improved myogenic control of blood pressure with dietary nitrate. Our findings indicate that dietary nitrate could be an effective strategy for stabilizing blood pressure and brain blood flow following transient ischemic attack.
Topics & Concepts
Blood pressureAutoregulationCerebral blood flowCerebral autoregulationBlood flowCardiologyNitrateMedicineInternal medicineAnesthesiaIschemiaHemodynamicsChemistryOrganic chemistryTraumatic Brain Injury and Neurovascular DisturbancesNitric Oxide and Endothelin EffectsEicosanoids and Hypertension Pharmacology