Fungal Extracellular Vesicles Are Involved in Intraspecies Intracellular Communication
Tamires A. Bitencourt, Otavio Hatanaka, André Moreira Pessoni, Mateus Silveira Freitas, Gabriel Trentin, Patrick Santos, Antônio Rossi, Nilce Maria Martinez-Rossi, Lysangela R. Alves, Arturo Casadevall, Márcio L. Rodrigues, Fausto Almeida
Abstract
Here, we report a study about extracellular vesicles (EVs) as communication mediators in fungi. Our results demonstrated the role of EVs from Candida albicans, Aspergillus fumigatus, and Paracoccidioides brasiliensis regulating the expression of target genes and phenotypic features. We asked whether fungal EVs play a role as message effectors. We show that fungal EVs are involved in fungal interaction systems as potent message effectors, and understanding their effects and mechanisms of action could be exploited in antifungal therapies.