A novel next‐generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: Results from safety studies in cynomolgus monkeys
Brian Lauritzen, Mads Bjelke, Olle Björkdahl, Esther Bloem, Kevin Keane, Marianne Kjalke, M Rossen, Solvej Lund Lippert, Karin Weldingh, Mikala Skydsgaard, Stine Kjellev
Topics & Concepts
PharmacodynamicsMedicinePartial thromboplastin timeIn vivoPharmacologySubcutaneous injectionTissue factorThrombosisEx vivoThrombin timeThromboplastinFactor IXPharmacokineticsCoagulationInternal medicineBiotechnologyBiologyHemophilia Treatment and ResearchBlood Coagulation and Thrombosis MechanismsBlood properties and coagulation