Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers
Jan D. Beck, Mustafa Diken, M Suchan, Michael Streuber, Elif Diken, LAURA D. KOLB, Lisa Allnoch, Fulvia Vascotto, Daniel T. Peters, Tim Beißert, Özlem Akilli‐Öztürk, Özlem Türeci, Sebastian Kreiter, Mathias Vormehr, Uğur Şahin
Topics & Concepts
MHC class ICD8ImmunologyBiologyImmunityMajor histocompatibility complexMessenger RNACytotoxic T cellT cellImmune systemGeneGeneticsIn vitroImmune Cell Function and InteractionCAR-T cell therapy researchImmunotherapy and Immune Responses