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Structural basis for the tethered peptide activation of adhesion GPCRs

Yu-Qi Ping, Peng Xiao, Fan Yang, Ru-Jia Zhao, Shengchao Guo, Yan Xu, Xiang Wu, Chao Zhang, Yan Lü, Fenghui Zhao, Fulai Zhou, Yue-Tong Xi, Wanchao Yin, Fengzhen Liu, Dongfang He, Daolai Zhang, Zhongliang Zhu, Yi Jiang, Lutao Du, Shiqing Feng, Torsten Schöneberg, Ines Liebscher, H. Eric Xu, Jin‐Peng Sun

2022Nature135 citationsDOI

Topics & Concepts

ReceptorTransmembrane domainChemistryBiophysicsIntramolecular forceG protein-coupled receptorBinding siteTransmembrane proteinStereochemistrySequence motifPeptideBiologyBiochemistryGeneReceptor Mechanisms and SignalingMass Spectrometry Techniques and ApplicationsNeuropeptides and Animal Physiology
Structural basis for the tethered peptide activation of adhesion GPCRs | Litcius