An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers <i>SKI</i> mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3
Yueyang Li, Yu Zhai, Tianling Wang, Siya Wang, Yu Tian, Zhiqun Bian, Yang Zhang, Chao Zhang, Minghan Liu, Changqing Li
Abstract
mRNA offers a promising therapeutic strategy to alleviate NP fibrosis and IVDD in the future.
Topics & Concepts
Intervertebral discExosomeNucleusCell biologyDegeneration (medical)Messenger RNAFOXO3ChemistryDownregulation and upregulationMicrovesiclesPathologyMedicinemicroRNAAnatomyBiologyGeneBiochemistrySpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitation