Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease
Courtney E. Vishy, Chardai J. Thomas, Thomas L. Vincent, Daniel K. Crawford, Matthew M. Goddeeris, Benjamin Freedman
Topics & Concepts
BiologyPolycystic kidney diseaseNonsense mutationInduced pluripotent stem cellPhenotypeCRISPRGeneticsLoss functionAutosomal dominant polycystic kidney diseaseGeneCancer researchCell biologyKidneyMissense mutationEmbryonic stem cellGenetic and Kidney Cyst DiseasesRenal and related cancersRenal cell carcinoma treatment